Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83677
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83677
Synonyms:
4-methoxy-N-[(6-methyl-4-oxidanylidene-chromen-3-yl)methylideneamino]benzamide | 4-methoxy-N-[(6-methyl-4-oxo-1-benzopyran-3-yl)methylideneamino]benzamide | 4-methoxy-N-[(6-methyl-4-oxochromen-3-yl)methylideneamino]benzamide | MLS001223932 | N-[(4-keto-6-methyl-chromen-3-yl)methyleneamino]-4-methoxy-benzamide | SMR000678711 | cid_24818628
Type:
Small organic molecule
Emp. Form.:
C19H16N2O4
Mol. Mass.:
336.3413
SMILES:
COc1ccc(cc1)C(=O)NN=Cc1coc2ccc(C)cc2c1=O
Structure:
Search PDB for entries with ligand similarity: