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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM47461
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59585±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM47461
Synonyms:
(E)-3-(5-Chloro-1-methyl-1H-imidazol-2-yl)-1-(2-hydroxy-phenyl)-propenone | (E)-3-(5-chloranyl-1-methyl-imidazol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one | (E)-3-(5-chloro-1-methyl-2-imidazolyl)-1-(2-hydroxyphenyl)-2-propen-1-one | (E)-3-(5-chloro-1-methyl-imidazol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one | (E)-3-(5-chloro-1-methylimidazol-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one | MLS000777800 | SMR000414242 | cid_5898784
Type:
Small organic molecule
Emp. Form.:
C13H11ClN2O2
Mol. Mass.:
262.692
SMILES:
Cn1c(Cl)cnc1\C=C\C(=O)c1ccccc1O
Structure:
Search PDB for entries with ligand similarity: