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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83817
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59640±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83817
Synonyms:
(5S,5aR,8aS,8bR)-2-(3-bromophenyl)-5-(4-chlorophenyl)-7-cyclohexyl-8b-ethyl-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrol[4,5-a]imidazole-1,3,6,8-diquinone | (5S,5aR,8aS,8bR)-2-(3-bromophenyl)-5-(4-chlorophenyl)-7-cyclohexyl-8b-ethyl-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone | MLS001066455 | SMR000471103 | cid_24792623
Type:
Small organic molecule
Emp. Form.:
C28H27BrClN3O4
Mol. Mass.:
584.889
SMILES:
CC[C@]12[C@@H]3[C@H]([C@H](N1C(=O)N(C2=O)c1cccc(Br)c1)c1ccc(Cl)cc1)C(=O)N(C1CCCCC1)C3=O
Structure:
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