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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83818
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59651±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83818
Synonyms:
3-(3,5-dimethyl-4-piperidin-1-ylsulfonyl-pyrazol-1-yl)-N-(4-ethylphenyl)propanamide | 3-(3,5-dimethyl-4-piperidin-1-ylsulfonylpyrazol-1-yl)-N-(4-ethylphenyl)propanamide | 3-(3,5-dimethyl-4-piperidinosulfonyl-pyrazol-1-yl)-N-(4-ethylphenyl)propionamide | 3-[3,5-dimethyl-4-(1-piperidinylsulfonyl)-1-pyrazolyl]-N-(4-ethylphenyl)propanamide | MLS001095837 | SMR000631473 | cid_16027733
Type:
Small organic molecule
Emp. Form.:
C21H30N4O3S
Mol. Mass.:
418.553
SMILES:
CCc1ccc(NC(=O)CCn2nc(C)c(c2C)S(=O)(=O)N2CCCCC2)cc1
Structure:
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