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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83828
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59638±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83828
Synonyms:
MLS002245437 | N-[3-(diethylsulfamoyl)-4-methyl-phenyl]-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]ethanamide | N-[3-(diethylsulfamoyl)-4-methyl-phenyl]-2-[(3,5-dimethylisoxazol-4-yl)methylthio]acetamide | N-[3-(diethylsulfamoyl)-4-methylphenyl]-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]acetamide | N-[3-(diethylsulfamoyl)-4-methylphenyl]-2-[(3,5-dimethyl-4-isoxazolyl)methylthio]acetamide | SMR001309089 | cid_4963639
Type:
Small organic molecule
Emp. Form.:
C19H27N3O4S2
Mol. Mass.:
425.565
SMILES:
CCN(CC)S(=O)(=O)c1cc(NC(=O)CSCc2c(C)noc2C)ccc1C
Structure:
Search PDB for entries with ligand similarity: