Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM77170
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59616±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM77170
Synonyms:
MLS000529376 | N-(2-furanylmethyl)-1-[1-(2-methylbutan-2-yl)-5-tetrazolyl]-1-(4-methylphenyl)-N-(thiophen-2-ylmethyl)methanamine | N-(furan-2-ylmethyl)-1-[1-(2-methylbutan-2-yl)-1,2,3,4-tetrazol-5-yl]-1-(4-methylphenyl)-N-(thiophen-2-ylmethyl)methanamine | N-(furan-2-ylmethyl)-1-[1-(2-methylbutan-2-yl)tetrazol-5-yl]-1-(4-methylphenyl)-N-(thiophen-2-ylmethyl)methanamine | SMR000121851 | [(1-tert-amyltetrazol-5-yl)-(p-tolyl)methyl]-(2-furfuryl)-(2-thenyl)amine | cid_3193727 | {[1-(1,1-Dimethyl-propyl)-1H-tetrazol-5-yl]-p-tolyl-methyl}-furan-2-ylmethyl-thiophen-2-ylmethyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H29N5OS
Mol. Mass.:
435.585
SMILES:
CCC(C)(C)n1nnnc1C(N(Cc1ccco1)Cc1cccs1)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: