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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM54853
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59631±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM54853
Synonyms:
BRD-A94563302-001-04-8 | N-[4-[3-(3,6-dichloro-9-carbazolyl)-2-hydroxypropoxy]phenyl]-N-methylacetamide | N-[4-[3-(3,6-dichlorocarbazol-9-yl)-2-hydroxy-propoxy]phenyl]-N-methyl-acetamide | N-[4-[3-(3,6-dichlorocarbazol-9-yl)-2-hydroxypropoxy]phenyl]-N-methylacetamide | N-[4-[3-[3,6-bis(chloranyl)carbazol-9-yl]-2-oxidanyl-propoxy]phenyl]-N-methyl-ethanamide | cid_2920939
Type:
Small organic molecule
Emp. Form.:
C24H22Cl2N2O3
Mol. Mass.:
457.349
SMILES:
CN(C(C)=O)c1ccc(OCC(O)Cn2c3ccc(Cl)cc3c3cc(Cl)ccc23)cc1
Structure:
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