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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM80068
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59617±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM80068
Synonyms:
MLS002693874 | SMR001559815 | [2-[3-(3-nitrophenyl)prop-2-enoyl]phenyl] acetate | [2-[3-(3-nitrophenyl)prop-2-enoyl]phenyl] ethanoate | acetic acid [2-[3-(3-nitrophenyl)-1-oxoprop-2-enyl]phenyl] ester | acetic acid [2-[3-(3-nitrophenyl)acryloyl]phenyl] ester | cid_252247
Type:
Small organic molecule
Emp. Form.:
C17H13NO5
Mol. Mass.:
311.2888
SMILES:
CC(=O)Oc1ccccc1C(=O)\C=C\c1cccc(c1)[N+]([O-])=O
Structure:
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