Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83839
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59562±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83839
Synonyms:
1,1-dimethyl-3-[4-(3-pyridinylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]thiourea | 1,1-dimethyl-3-[4-(3-pyridylmethyl)-5-thioxo-1,2,4-dithiazolidin-3-ylidene]thiourea | 1,1-dimethyl-3-[4-(pyridin-3-ylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]thiourea | MLS002701553 | SMR001565154 | cid_371401
Type:
Small organic molecule
Emp. Form.:
C11H12N4S4
Mol. Mass.:
328.5
SMILES:
CN(C)C(=S)N=c1ssc(=S)n1Cc1cccnc1
Structure:
Search PDB for entries with ligand similarity: