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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83845
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59538±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83845
Synonyms:
6-Thio-8-N-butylthiotheophylline | 8-(butylthio)-1,3-dimethyl-6-sulfanylidene-7H-purin-2-one | 8-(butylthio)-1,3-dimethyl-6-thioxo-7H-purin-2-one | 8-butylsulfanyl-1,3-dimethyl-6-sulfanylidene-7H-purin-2-one | MLS002703310 | SMR001570033 | cid_3034531
Type:
Small organic molecule
Emp. Form.:
C11H16N4OS2
Mol. Mass.:
284.401
SMILES:
CCCCSc1nc2n(C)c(=O)n(C)c(=S)c2[nH]1
Structure:
Search PDB for entries with ligand similarity: