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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83851
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59608±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83851
Synonyms:
3,3-bis(benzenesulfonyl)propanoic acid tert-butyl ester | 3,3-dibesylpropionic acid tert-butyl ester | MLS002920080 | SMR001797677 | cid_279782 | tert-butyl 3,3-bis(benzenesulfonyl)propanoate | tert-butyl 3,3-bis(phenylsulfonyl)propanoate
Type:
Small organic molecule
Emp. Form.:
C19H22O6S2
Mol. Mass.:
410.504
SMILES:
CC(C)(C)OC(=O)CC(S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Structure:
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