Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM83896
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
3970±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM83896
Synonyms:
2-Nitro-benzoic acid 3-(3-benzotriazol-1-yl-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-phenyl ester | 2-nitrobenzoic acid [3-[[3-(1-benzotriazolyl)-1,4-dioxo-2-naphthalenyl]amino]phenyl] ester | 2-nitrobenzoic acid [3-[[3-(benzotriazol-1-yl)-1,4-diketo-2-naphthyl]amino]phenyl] ester | MLS000557365 | SMR000148282 | [3-[[3-(benzotriazol-1-yl)-1,4-bis(oxidanylidene)naphthalen-2-yl]amino]phenyl] 2-nitrobenzoate | [3-[[3-(benzotriazol-1-yl)-1,4-dioxonaphthalen-2-yl]amino]phenyl] 2-nitrobenzoate | cid_1423853
Type:
Small organic molecule
Emp. Form.:
C29H17N5O6
Mol. Mass.:
531.4752
SMILES:
[O-][N+](=O)c1ccccc1C(=O)Oc1cccc(c1)\[NH+]=C1\[C-](C(=O)c2ccccc2C1=O)[n+]1n[n-]c2ccccc12
Structure:
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