Reaction Details Report a problem with these data
Target
Cysteine protease ATG4B
Ligand
BDBM84009
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2
IC50
19900±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2 PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM84009
Synonyms:
5-amino-N-(2,5-dimethoxyphenyl)-1-(2-methylbenzyl)-1H-1,2,3-triazole-4-carboxamide | 5-amino-N-(2,5-dimethoxyphenyl)-1-(2-methylbenzyl)triazole-4-carboxamide | 5-amino-N-(2,5-dimethoxyphenyl)-1-[(2-methylphenyl)methyl]-4-triazolecarboxamide | 5-amino-N-(2,5-dimethoxyphenyl)-1-[(2-methylphenyl)methyl]triazole-4-carboxamide | 5-azanyl-N-(2,5-dimethoxyphenyl)-1-[(2-methylphenyl)methyl]-1,2,3-triazole-4-carboxamide | MLS000044850 | SMR000022960 | cid_3241438
Type:
Small organic molecule
Emp. Form.:
C19H21N5O3
Mol. Mass.:
367.4017
SMILES:
COc1ccc(OC)c(NC(=O)c2nnn(Cc3ccccc3C)c2N)c1
Structure:
Search PDB for entries with ligand similarity: