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Target
Multidrug efflux pump
Ligand
BDBM84144
Substrate
n/a
Meas. Tech.
Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1
EC50
14000±n/a nM
Citation
 PubChem, PC Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1 PubChem Bioassay (2011)[AID] 
Target
Name:
Multidrug efflux pump
Synonyms:
Candida albicans strain ATCC 10261 multidrug efflux pump (MDR1) gene, MDR1-A allele, complete cds
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62915.82
Organism:
Candida albicans
Description:
Q09GR2
Residue:
564
Sequence:
MHYRFLRDSFVGRVTYHLSKHKYFAHPEEAKDYIVPEKYLADYKPTLADDTSINFEKEEIDNQGEPNSSQSSSSNNTIVDNNNNNDNDVDGDKIVVTWDGDDDPENPQNWPTLQKAFFIFQISFLTTSVYMGSAVYTPGIEELMHDFGIGRVVATLPLTLFVIGYGVGPLVFSPMSENAIFGRTSIYIITLFLFVILQIPTALVNNIAGLCILRFLGGFFASPCLATGGASVADVVKFWNLPVGLAAWSLGAVCGPSFGPFFGSILTVKASWRWTFWFMCIISGFSFVMLCFTLPETFGKTLLYRKAKRLRAITGNDRITSEGEIENSKMTSHELIIDTLWRPLEITVMEPVVLLINIYIAMVYSILYLFFEVFPIYFVGVKHFTLVELGTTYMSIVIGIVIAAFIYIPVIRQKFTKPILRQEQVFPEVFIPIAIVGGILLTSGLFIFGWSANRTTHWVGPLFGAATTASGAFLIFQTLFNFMGASFKPHYIASVFASNDLFRSVIASVFPLFGAPLFDNLATPEYPVAWGSSVLGFITLVMIAIPVLFYLNGPKLRARSKYAN
  
Inhibitor
Name:
BDBM84144
Synonyms:
9-(3,4-dichlorophenyl)-2-(2-furanyl)-8-oxo-7H-purine-6-carboxamide | 9-(3,4-dichlorophenyl)-2-(2-furyl)-8-keto-7H-purine-6-carboxamide | 9-(3,4-dichlorophenyl)-2-(furan-2-yl)-8-oxidanylidene-7H-purine-6-carboxamide | 9-(3,4-dichlorophenyl)-2-(furan-2-yl)-8-oxo-7H-purine-6-carboxamide | MLS000419066 | SMR000320404 | cid_7119032
Type:
Small organic molecule
Emp. Form.:
C16H9Cl2N5O3
Mol. Mass.:
390.18
SMILES:
NC(=O)c1nc(nc2n(-c3ccc(Cl)c(Cl)c3)c(=O)[nH]c12)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: