Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM84202
Substrate
n/a
Meas. Tech.
Dose response for HTS for Beta-2AR agonists via FAP method from CP1
EC50
327±n/a nM
Citation
 PubChem, PC Dose response for HTS for Beta-2AR agonists via FAP method from CP1 PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM84202
Synonyms:
2,6-dimethyl-4-(1-phenyl-3-thiophen-2-yl-4-pyrazolyl)-1,4-dihydropyridine-3,5-dicarbonitrile | 2,6-dimethyl-4-(1-phenyl-3-thiophen-2-yl-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarbonitrile | 2,6-dimethyl-4-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarbonitrile | 2,6-dimethyl-4-[1-phenyl-3-(2-thienyl)pyrazol-4-yl]-1,4-dihydropyridine-3,5-dicarbonitrile | MLS000048603 | SMR000060591 | cid_2998304
Type:
Small organic molecule
Emp. Form.:
C22H17N5S
Mol. Mass.:
383.469
SMILES:
CC1=NC(C)=C(C#N)C(C1C#N)c1cn(nc1-c1cccs1)-c1ccccc1 |t:1,4|
Structure:
Search PDB for entries with ligand similarity: