Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM84216
Substrate
n/a
Meas. Tech.
Dose response for HTS for Beta-2AR agonists via FAP method from CP1
EC50
220±n/a nM
Citation
 PubChem, PC Dose response for HTS for Beta-2AR agonists via FAP method from CP1 PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM84216
Synonyms:
5-(2-furanyl)-N-[1-[(4-methylphenyl)methyl]-3-pyrazolyl]-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide | 5-(2-furyl)-N-[1-(4-methylbenzyl)pyrazol-3-yl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | 5-(furan-2-yl)-N-[1-[(4-methylphenyl)methyl]pyrazol-3-yl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | 5-Furan-2-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid [1-(4-methyl-benzyl)-1H-pyrazol-3-yl]-amide | MLS000525398 | SMR000122272 | cid_1165076
Type:
Small organic molecule
Emp. Form.:
C23H17F3N6O2
Mol. Mass.:
466.4153
SMILES:
Cc1ccc(Cn2ccc(NC(=O)c3cc4nc(cc(n4n3)C(F)(F)F)-c3ccco3)n2)cc1
Structure:
Search PDB for entries with ligand similarity: