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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50021895
Substrate
n/a
Ki
606±n/a nM
Comments
PDSP_660
Citation
 Pristupa, ZB; Wilson, JM; Hoffman, BJ; Kish, SJ; Niznik, HB Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding. Mol Pharmacol 45:125-35 (1994) [PubMed] 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50021895
Synonyms:
4-(3,4-Dichloro-phenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline | 4-(3,4-Dichloro-phenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline(Diclofensive) | CHEMBL287257 | DICLOFENSINE,(+) | DICLOFENSINE,(-) | Diclofensine
Type:
Small organic molecule
Emp. Form.:
C17H17Cl2NO
Mol. Mass.:
322.229
SMILES:
COc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1
Structure:
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