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Target
5-hydroxytryptamine receptor 1E
Ligand
BDBM50031942
Substrate
n/a
Ki
300±n/a nM
Comments
PDSP_1230
Citation
 Lovenberg, TW; Erlander, MG; Baron, BM; Racke, M; Slone, AL; Siegel, BW; Craft, CM; Burns, JE; Danielson, PE; Sutcliffe, JG Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Proc Natl Acad Sci U S A 90:2184-8 (1993) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1E
Synonyms:
5-HT1E | HTR1E
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41709.22
Organism:
RAT
Description:
5-HT1E HTR1E RAT::G5B6Z9
Residue:
365
Sequence:
MNLTNYTTEASVAVKPKTVTEKMLICMTLVIITTLTMLLNSAVIMAICTTRKLHQPANYLICSLAVTDLLVAVLVMPLSVMYIVMDNWRLGYFICEVWLSVDMTCCTCSILHLCVIALDRYWAITKAIEYARKRTARRAGLMILTVWTISIFISMPPLFWRSHRQVSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKIHTSIRIPPFDNDLDQPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVGDFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
  
Inhibitor
Name:
BDBM50031942
Synonyms:
(6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (1-hydroxymethyl-propyl)-amide | (6aR,9R)-4,7-Dimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((S)-1-hydroxymethyl-propyl)-amide | (6aR,9R)-4-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (1-hydroxymethyl-propyl)-amide | (6aR,9R)-5,7-Dimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid diethylamide | (methylsergide)4,7-Dimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (1-hydroxymethyl-propyl)-amide | 4,7-Dimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (1-hydroxymethyl-propyl)-amide | CHEMBL1065 | METHYSERGIDE | Sansert
Type:
Small organic molecule
Emp. Form.:
C21H27N3O2
Mol. Mass.:
353.458
SMILES:
CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34 |r,c:24|
Structure:
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