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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50239074
Substrate
n/a
Meas. Tech.
ChEMBL_1665216 (CHEMBL4015012)
Ki
270±n/a nM
Citation
 Luan, S; Ge, Q; Chen, Y; Dai, M; Yang, J; Li, K; Liu, D; Zhao, L Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors. Bioorg Med Chem Lett 27:1943-1948 (2017) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50239074
Synonyms:
CHEMBL4071224
Type:
Small organic molecule
Emp. Form.:
C33H35ClN2O5
Mol. Mass.:
575.094
SMILES:
Cc1cc(OCCCn2c(cc3ccc(OCc4ccccc4C(O)=O)cc23)C(=O)N2CCCCC2)cc(C)c1Cl
Structure:
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