Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM50239166
Substrate
n/a
Meas. Tech.
ChEMBL_1665387 (CHEMBL4015183)
IC50
10000±n/a nM
Citation
 Qu, C; Ding, M; Zhu, Y; Lu, Y; Du, J; Miller, M; Tian, J; Zhu, J; Xu, J; Wen, M; Er-Bu, A; Wang, J; Xiao, Y; Wu, M; McManus, OB; Li, M; Wu, J; Luo, HR; Cao, Z; Shen, B; Wang, H; Zhu, MX; Hong, X Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692 (2017) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
TRPC4_MOUSE | Trpc4 | Trrp4 | alternatively spliced Trp4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
111587.67
Organism:
Mus musculus
Description:
Q9QUQ5
Residue:
974
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL
  
Inhibitor
Name:
BDBM50239166
Synonyms:
CHEMBL4083411
Type:
Small organic molecule
Emp. Form.:
C24H21BrFN5O2
Mol. Mass.:
510.358
SMILES:
Cc1nn2c(O)cc(nc2c1-c1ccc(F)cc1)C1CCN(CC1)C(=O)c1ccc(Br)nc1
Structure:
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