Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM50239164
Substrate
n/a
Meas. Tech.
ChEMBL_1665387 (CHEMBL4015183)
IC50
35000±n/a nM
Citation
 Qu, C; Ding, M; Zhu, Y; Lu, Y; Du, J; Miller, M; Tian, J; Zhu, J; Xu, J; Wen, M; Er-Bu, A; Wang, J; Xiao, Y; Wu, M; McManus, OB; Li, M; Wu, J; Luo, HR; Cao, Z; Shen, B; Wang, H; Zhu, MX; Hong, X Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692 (2017) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
TRPC4_MOUSE | Trpc4 | Trrp4 | alternatively spliced Trp4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
111587.67
Organism:
Mus musculus
Description:
Q9QUQ5
Residue:
974
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL
  
Inhibitor
Name:
BDBM50239164
Synonyms:
CHEMBL4080748
Type:
Small organic molecule
Emp. Form.:
C21H23FN4O2
Mol. Mass.:
382.4313
SMILES:
CCC(=O)N1CCC(CC1)c1cc(O)n2nc(C)c(-c3ccc(F)cc3)c2n1
Structure:
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