Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 7
Ligand
BDBM50239167
Substrate
n/a
Meas. Tech.
ChEMBL_1665418 (CHEMBL4015214)
EC50
1130±n/a nM
Citation
 Qu, C; Ding, M; Zhu, Y; Lu, Y; Du, J; Miller, M; Tian, J; Zhu, J; Xu, J; Wen, M; Er-Bu, A; Wang, J; Xiao, Y; Wu, M; McManus, OB; Li, M; Wu, J; Luo, HR; Cao, Z; Shen, B; Wang, H; Zhu, MX; Hong, X Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692 (2017) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 7
Synonyms:
Short transient receptor potential channel 7 | TRP-7 | TRP7 | TRPC7 | TRPC7_HUMAN | Transient receptor protein 7 | hTRP7
Type:
PROTEIN
Mol. Mass.:
99572.61
Organism:
Homo sapiens
Description:
ChEMBL_117404
Residue:
862
Sequence:
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
  
Inhibitor
Name:
BDBM50239167
Synonyms:
CHEMBL1496110
Type:
Small organic molecule
Emp. Form.:
C21H23FN4O3
Mol. Mass.:
398.4307
SMILES:
CCOC(=O)N1CCC(CC1)c1cc(O)n2nc(C)c(-c3ccc(F)cc3)c2n1
Structure:
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