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Target
Bromodomain testis-specific protein
Ligand
BDBM50239573
Substrate
n/a
Meas. Tech.
ChEBML_1666425
Ki
>40000±n/a nM
Citation
 Ayoub, AM; Hawk, LML; Herzig, RJ; Jiang, J; Wisniewski, AJ; Gee, CT; Zhao, P; Zhu, JY; Berndt, N; Offei-Addo, NK; Scott, TG; Qi, J; Bradner, JE; Ward, TR; Schönbrunn, E; Georg, GI; Pomerantz, WCK BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. J Med Chem 60:4805-4817 (2017) [PubMed]  Article 
Target
Name:
Bromodomain testis-specific protein
Synonyms:
BRDT | BRDT_HUMAN | Bromodomain and extra-terminal motif (BET) | CT9 | Cancer/testis antigen 9 | RING3-like protein
Type:
PROTEIN
Mol. Mass.:
107982.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502985
Residue:
947
Sequence:
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
  
Inhibitor
Name:
BDBM50239573
Synonyms:
CHEMBL4102160
Type:
Small organic molecule
Emp. Form.:
C18H17N3O5
Mol. Mass.:
355.3447
SMILES:
COc1ccc(cc1)C1C2=C(COC2=O)Nc2c1c(=O)n(C)c(=O)n2C |t:10|
Structure:
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