Reaction Details Report a problem with these data
Target
Prolyl hydroxylase EGLN2
Ligand
BDBM50239899
Substrate
n/a
Meas. Tech.
ChEMBL_1667508 (CHEMBL4017304)
IC50
670±n/a nM
Citation
 Ahmed, S; Ayscough, A; Barker, GR; Canning, HE; Davenport, R; Downham, R; Harrison, D; Jenkins, K; Kinsella, N; Livermore, DG; Wright, S; Ivetac, AD; Skene, R; Wilkens, SJ; Webster, NA; Hendrick, AG 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem 60:5663-5672 (2017) [PubMed]  Article 
Target
Name:
Prolyl hydroxylase EGLN2
Synonyms:
EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1)
Type:
Protein
Mol. Mass.:
43657.01
Organism:
Homo sapiens (Human)
Description:
Q96KS0
Residue:
407
Sequence:
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
  
Inhibitor
Name:
BDBM50239899
Synonyms:
CHEMBL4103861 | US10287286, Example 1
Type:
Small organic molecule
Emp. Form.:
C12H7Cl2N3
Mol. Mass.:
264.11
SMILES:
Clc1ccc(c(Cl)c1)-c1cccc2ncnn12
Structure:
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