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Target
P2Y purinoceptor 12
Ligand
BDBM50000897
Substrate
n/a
Meas. Tech.
ChEMBL_89718 (CHEMBL696421)
EC50
130±n/a nM
Citation
 Meanwell, NA; Pearce, BC; Roth, HR; Smith, EC; Wedding, DL; Wright, JJ; Buchanan, JO; Baryla, UM; Gamberdella, M; Gillespie, E Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. J Med Chem 35:2672-87 (1992) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
P2Y(AC) | P2Y12 | ADPG-R | SP1999 | ADP-glucose receptor | P2T(AC) | P2Y purinoceptor 12 | P2Y(ADP) | P2Y(cyc) | P2Y12 platelet ADP receptor | P2Y12_HUMAN | P2RY12 | HORK3 | Purinergic receptor P2Y12
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Human
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50000897
Synonyms:
CHEMBL90414 | 7-(4-Oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
O=C(CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1)N1CCCCC1
Structure:
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