Reaction Details Report a problem with these data
Target
ELAV-like protein 1
Ligand
BDBM50240687
Substrate
n/a
Meas. Tech.
ChEMBL_1668505 (CHEMBL4018393)
IC50
41900±n/a nM
Citation
 Nasti, R; Rossi, D; Amadio, M; Pascale, A; Unver, MY; Hirsch, AKH; Collina, S Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs. J Med Chem 60:8257-8267 (2017) [PubMed]  Article 
Target
Name:
ELAV-like protein 1
Synonyms:
ELAV1_HUMAN | ELAVL1 | HUR | Hu-antigen R
Type:
PROTEIN
Mol. Mass.:
36102.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_654855
Residue:
326
Sequence:
MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
  
Inhibitor
Name:
BDBM50240687
Synonyms:
CHEMBL4066821
Type:
Small organic molecule
Emp. Form.:
C35H37ClN2O11
Mol. Mass.:
697.128
SMILES:
CO[C@H]1[C@@H](OC(=O)c2ccc[nH]2)[C@@H](O)C(Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC(C)=C(C)C)c4)c(=O)oc3c2Cl)OC1(C)C |r,wU:12.13,3.3,2.1,(74.51,-50.52,;73.18,-51.28,;71.84,-50.52,;70.5,-51.28,;70.5,-52.82,;71.83,-53.6,;73.17,-52.83,;71.83,-55.14,;70.58,-56.04,;71.05,-57.51,;72.59,-57.51,;73.07,-56.05,;69.18,-50.51,;67.84,-51.27,;69.19,-48.98,;67.85,-48.2,;66.52,-48.98,;66.52,-50.52,;65.18,-51.28,;63.85,-50.52,;62.54,-51.28,;62.54,-52.83,;61.21,-50.52,;59.88,-51.29,;59.88,-52.84,;61.22,-53.6,;58.55,-53.61,;58.55,-55.16,;57.22,-55.94,;55.88,-55.16,;54.54,-55.93,;55.88,-53.62,;54.55,-52.85,;54.55,-51.31,;55.88,-50.53,;53.21,-50.54,;53.21,-48.99,;51.88,-51.31,;57.21,-52.85,;61.19,-48.98,;59.85,-48.21,;62.53,-48.21,;63.86,-48.98,;65.19,-48.21,;65.19,-46.67,;70.51,-48.19,;71.84,-48.97,;72.6,-47.63,;73.38,-48.96,)|
Structure:
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