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Target
Mu-type opioid receptor
Ligand
BDBM50240882
Substrate
n/a
Meas. Tech.
ChEMBL_1669276 (CHEMBL4019164)
EC50
10000±n/a nM
Citation
 Stepan, AF; Claffey, MM; Reese, MR; Balan, G; Barreiro, G; Barricklow, J; Bohanon, MJ; Boscoe, BP; Cappon, GD; Chenard, LK; Cianfrogna, J; Chen, L; Coffman, KJ; Drozda, SE; Dunetz, JR; Ghosh, S; Hou, X; Houle, C; Karki, K; Lazzaro, JT; Mancuso, JY; Marcek, JM; Miller, EL; Moen, MA; O'Neil, S; Sakurada, I; Skaddan, M; Parikh, V; Smith, DL; Trapa, P; Tuttle, JB; Verhoest, PR; Walker, DP; Won, A; Wright, AS; Whritenour, J; Zasadny, K; Zaleska, MM; Zhang, L; Shaffer, CL Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. J Med Chem 60:7764-7780 (2017) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50240882
Synonyms:
CHEMBL4063837
Type:
Small organic molecule
Emp. Form.:
C18H23N3O3
Mol. Mass.:
329.3935
SMILES:
CC(C)(C)C[C@@H]1COCc2nc(OCc3ccccn3)cc(=O)n12 |r|
Structure:
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