Reaction Details Report a problem with these data
Target
Dual specificity protein kinase CLK1
Ligand
BDBM50242618
Substrate
n/a
Meas. Tech.
ChEMBL_1671985 (CHEMBL4022014)
IC50
<10000±n/a nM
Citation
 Karthikeyan, C; Jharia, P; Waiker, DK; Nusbaum, AC; Amawi, H; Kirwen, EM; Christman, R; Arudra, SKC; Meijer, L; Tiwari, AK; Trivedi, P N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1?/? inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorg Med Chem Lett 27:2663-2667 (2017) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty
Type:
PROTEIN
Mol. Mass.:
57124.52
Organism:
Mus musculus
Description:
ChEMBL_1502245
Residue:
483
Sequence:
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT
  
Inhibitor
Name:
BDBM50242618
Synonyms:
CHEMBL4099804
Type:
Small organic molecule
Emp. Form.:
C19H16ClN5O2
Mol. Mass.:
381.816
SMILES:
COc1cc2ncnc(Nc3cc([nH]n3)-c3ccc(Cl)cc3)c2cc1OC
Structure:
Search PDB for entries with ligand similarity: