Reaction Details Report a problem with these data
Target
Phospholipase A-2-activating protein
Ligand
BDBM50042034
Substrate
n/a
Meas. Tech.
ChEMBL_1674708 (CHEMBL4024851)
IC50
11±n/a nM
Citation
 Jackson, PA; Widen, JC; Harki, DA; Brummond, KM Covalent Modifiers: A Chemical Perspective on the Reactivity of?,?-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. J Med Chem 60:839-885 (2017) [PubMed]  Article 
Target
Name:
Phospholipase A-2-activating protein
Synonyms:
PLAA | PLAP | PLAP_HUMAN
Type:
PROTEIN
Mol. Mass.:
87154.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610122
Residue:
795
Sequence:
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL
  
Inhibitor
Name:
BDBM50042034
Synonyms:
(5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 | CHEMBL1077979
Type:
Small organic molecule
Emp. Form.:
C19H22O7
Mol. Mass.:
362.3738
SMILES:
COc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O |r,c:19,t:10|
Structure:
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