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Target
RNA 5'-monophosphate methyltransferase
Ligand
BDBM50247634
Substrate
n/a
Meas. Tech.
ChEMBL_1678259 (CHEMBL4028402)
IC50
40000±n/a nM
Citation
 Babault, N; Allali-Hassani, A; Li, F; Fan, J; Yue, A; Ju, K; Liu, F; Vedadi, M; Liu, J; Jin, J Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). J Med Chem 61:1541-1551 (2018) [PubMed]  Article 
Target
Name:
RNA 5'-monophosphate methyltransferase
Synonyms:
2.1.1.- | BCDIN3 domain-containing protein | BCDIN3D | BN3D2_HUMAN | Pre-miRNA 5'-monophosphate methyltransferase
Type:
PROTEIN
Mol. Mass.:
33201.33
Organism:
Homo sapiens
Description:
ChEMBL_109829
Residue:
292
Sequence:
MAVPTELDGGSVKETAAEEESRVLAPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPESPENGPILGLDVGCNSGDLSVALYKHFLSLPDGETCSDASREFRLLCCDIDPVLVKRAEKECPFPDALTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCHYLLVEPQPWKCYRAAARRLRKLGLHDFDHFHSLAIRGDMPNQIVQILTQDHGMELICCFGNTSWDRSLLLFRAKQTIETHPIPESLIEKGKEKNRLSFQKQ
  
Inhibitor
Name:
BDBM50247634
Synonyms:
CHEMBL4067973
Type:
Small organic molecule
Emp. Form.:
C24H32N8O6
Mol. Mass.:
528.5609
SMILES:
N[C@@H](CCCN(CCc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Structure:
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