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Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50249991
Substrate
n/a
Meas. Tech.
ChEBML_1680835
Kd
15±n/a nM
Citation
 Jiang, Y; Zhuang, C; Chen, L; Lu, J; Dong, G; Miao, Z; Zhang, W; Li, J; Sheng, C Structural Biology-Inspired Discovery of Novel KRAS-PDE? Inhibitors. J Med Chem 60:9400-9406 (2017) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50249991
Synonyms:
CHEMBL4069561
Type:
Small organic molecule
Emp. Form.:
C36H34F2N4O2
Mol. Mass.:
592.6776
SMILES:
Fc1ccccc1C1Nc2ccccc2C(=O)N1CC1CCC(CN2C(Nc3ccccc3C2=O)c2ccccc2F)CC1 |(30.58,-33,;31.92,-32.24,;33.26,-33.01,;34.59,-32.25,;34.59,-30.7,;33.26,-29.93,;31.94,-30.7,;30.61,-29.92,;29.26,-30.69,;27.92,-29.91,;26.59,-30.69,;25.26,-29.91,;25.26,-28.37,;26.59,-27.6,;27.92,-28.36,;29.26,-27.58,;29.26,-26.04,;30.61,-28.36,;31.94,-27.6,;31.95,-26.06,;33.29,-25.3,;33.3,-23.76,;31.97,-22.99,;31.98,-21.45,;33.32,-20.68,;33.32,-19.15,;34.67,-18.4,;36,-19.17,;37.33,-18.43,;38.64,-19.2,;38.62,-20.74,;37.29,-21.49,;35.98,-20.71,;34.64,-21.47,;34.63,-23.01,;31.99,-18.38,;30.66,-19.14,;29.33,-18.37,;29.33,-16.82,;30.67,-16.06,;32,-16.84,;33.34,-16.07,;30.63,-23.75,;30.62,-25.29,)|
Structure:
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