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Target
Calmodulin-domain protein kinase 1
Ligand
BDBM50250015
Substrate
n/a
Meas. Tech.
ChEBML_1680859
IC50
14±n/a nM
Citation
 Rutaganira, FU; Barks, J; Dhason, MS; Wang, Q; Lopez, MS; Long, S; Radke, JB; Jones, NG; Maddirala, AR; Janetka, JW; El Bakkouri, M; Hui, R; Shokat, KM; Sibley, LD Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. J Med Chem 60:9976-9989 (2017) [PubMed]  Article 
Target
Name:
Calmodulin-domain protein kinase 1
Synonyms:
Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57248.42
Organism:
Toxoplasma gondii
Description:
n/a
Residue:
507
Sequence:
MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN
  
Inhibitor
Name:
BDBM50250015
Synonyms:
CHEMBL4065764 | US11208411, Compound GXJ186
Type:
Small organic molecule
Emp. Form.:
C15H16ClN5S
Mol. Mass.:
333.839
SMILES:
CC(C)(C)n1nc(Sc2cccc(Cl)c2)c2c(N)ncnc12
Structure:
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