Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 7
Ligand
BDBM50250518
Substrate
n/a
Meas. Tech.
ChEBML_1681824
Kd
220±n/a nM
Citation
 Watson, GM; Kulkarni, K; Sang, J; Ma, X; Gunzburg, MJ; Perlmutter, P; Wilce, MCJ; Wilce, JA Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J Med Chem 60:9349-9359 (2017) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 7
Synonyms:
B47 | Epidermal growth factor receptor GRB-7 | GRB7 | GRB7 adapter protein | GRB7_HUMAN
Type:
PROTEIN
Mol. Mass.:
59700.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_699661
Residue:
532
Sequence:
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
  
Inhibitor
Name:
BDBM50250518
Synonyms:
CHEMBL4093671
Type:
Small organic molecule
Emp. Form.:
C51H66N12O18S
Mol. Mass.:
1167.204
SMILES:
NC(=O)C[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc(CC(O)=O)cc2)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CSCC(=O)N2)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: