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Target
Growth factor receptor-bound protein 7
Ligand
BDBM50250523
Substrate
n/a
Meas. Tech.
ChEMBL_1681823 (CHEMBL4032100)
Kd
2560±n/a nM
Citation
 Watson, GM; Kulkarni, K; Sang, J; Ma, X; Gunzburg, MJ; Perlmutter, P; Wilce, MCJ; Wilce, JA Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J Med Chem 60:9349-9359 (2017) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 7
Synonyms:
B47 | Epidermal growth factor receptor GRB-7 | GRB7 | GRB7 adapter protein | GRB7_HUMAN
Type:
PROTEIN
Mol. Mass.:
59700.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_699661
Residue:
532
Sequence:
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
  
Inhibitor
Name:
BDBM50250523
Synonyms:
CHEMBL4101397
Type:
Small organic molecule
Emp. Form.:
C49H64N12O17S
Mol. Mass.:
1125.168
SMILES:
NC(=O)C[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CSCC(=O)N2)C(N)=O |r|
Structure:
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