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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50250592
Substrate
n/a
Meas. Tech.
ChEBML_1681948
EC50
16±n/a nM
Citation
 García-Cárceles, J; Decara, JM; Vázquez-Villa, H; Rodríguez, R; Codesido, E; Cruces, J; Brea, J; Loza, MI; Alén, F; Botta, J; McCormick, PJ; Ballesteros, JA; Benhamú, B; Rodríguez de Fonseca, F; López-Rodríguez, ML A Positive Allosteric Modulator of the Serotonin 5-HT J Med Chem 60:9575-9584 (2017) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50250592
Synonyms:
CHEMBL4095079
Type:
Small organic molecule
Emp. Form.:
C21H19N3
Mol. Mass.:
313.3957
SMILES:
C(Nc1cccnc1)c1cn(Cc2ccccc2)c2ccccc12
Structure:
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