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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50251360
Substrate
n/a
Meas. Tech.
ChEMBL_1683725 (CHEMBL4034204)
IC50
3500±n/a nM
Citation
 Nencetti, S; La Motta, C; Rossello, A; Sartini, S; Nuti, E; Ciccone, L; Orlandini, E N-(Aroyl)-N-(arylmethyloxy)-?-alanines: Selective inhibitors of aldose reductase. Bioorg Med Chem 25:3068-3076 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
1.1.1.21 | 1.1.1.300 | 1.1.1.372 | 1.1.1.54 | 20-alpha-HSD | 20-alpha-hydroxysteroid dehydrogenase | AKR1B1 | ALDR_BOVIN | Aldehyde reductase | Aldo-keto reductase family 1 member B1 | Aldose reductase
Type:
PROTEIN
Mol. Mass.:
35917.32
Organism:
Bos taurus
Description:
ChEMBL_17058
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEKVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50251360
Synonyms:
CHEMBL4077795
Type:
Small organic molecule
Emp. Form.:
C17H17NO5
Mol. Mass.:
315.3206
SMILES:
COc1ccc(cc1)C(=O)N(CC(O)=O)OCc1ccccc1
Structure:
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