Reaction Details Report a problem with these data
Target
Nuclear factor of activated T-cells, cytoplasmic 1
Ligand
BDBM50251475
Substrate
n/a
Meas. Tech.
ChEBML_1683764
EC50
9800±n/a nM
Citation
 Shaw, SJ; Goff, DA; Lin, N; Singh, R; Li, W; McLaughlin, J; Baltgalvis, KA; Payan, DG; Kinsella, TM Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus. Bioorg Med Chem Lett 27:2617-2621 (2017) [PubMed]  Article 
Target
Name:
Nuclear factor of activated T-cells, cytoplasmic 1
Synonyms:
NF-ATc | NF-ATc1 | NFAC1_HUMAN | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | Nuclear factor of activated T-cells cytoplasmic 1 | Nuclear factor of activated T-cells, cytoplasmic 1
Type:
PROTEIN
Mol. Mass.:
101251.15
Organism:
Homo sapiens
Description:
ChEMBL_11335
Residue:
943
Sequence:
MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
  
Inhibitor
Name:
BDBM50251475
Synonyms:
CHEMBL4090889
Type:
Small organic molecule
Emp. Form.:
C13H12N4O
Mol. Mass.:
240.2606
SMILES:
COc1cccc2c(c[nH]c12)-c1ccnc(N)n1
Structure:
Search PDB for entries with ligand similarity: