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Target
Retinoblastoma-associated protein
Ligand
BDBM50251842
Substrate
n/a
Meas. Tech.
ChEBML_1684306
IC50
>100000±n/a nM
Citation
 Kulkarni, MR; Mane, MS; Ghosh, U; Sharma, R; Lad, NP; Srivastava, A; Kulkarni-Almeida, A; Kharkar, PS; Khedkar, VM; Pandit, SS Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors. Eur J Med Chem 134:366-378 (2017) [PubMed]  Article 
Target
Name:
Retinoblastoma-associated protein
Synonyms:
RB1 | RB_HUMAN | Rb | pRb | pp110 | retinoblastoma
Type:
Other Protein Type
Mol. Mass.:
106170.80
Organism:
Homo sapiens (Human)
Description:
P06400
Residue:
928
Sequence:
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
  
Inhibitor
Name:
BDBM50251842
Synonyms:
CHEMBL4082537
Type:
Small organic molecule
Emp. Form.:
C17H17N3O2S
Mol. Mass.:
327.401
SMILES:
O=S(=O)(NC1CCCc2c1[nH]c1ccccc21)c1cccnc1
Structure:
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