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Target
Retinoblastoma-associated protein
Ligand
BDBM50251850
Substrate
n/a
Meas. Tech.
ChEBML_1684306
IC50
4100±n/a nM
Citation
 Kulkarni, MR; Mane, MS; Ghosh, U; Sharma, R; Lad, NP; Srivastava, A; Kulkarni-Almeida, A; Kharkar, PS; Khedkar, VM; Pandit, SS Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors. Eur J Med Chem 134:366-378 (2017) [PubMed]  Article 
Target
Name:
Retinoblastoma-associated protein
Synonyms:
RB1 | RB_HUMAN | Rb | pRb | pp110 | retinoblastoma
Type:
Other Protein Type
Mol. Mass.:
106170.80
Organism:
Homo sapiens (Human)
Description:
P06400
Residue:
928
Sequence:
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
  
Inhibitor
Name:
BDBM50251850
Synonyms:
CHEMBL4077816
Type:
Small organic molecule
Emp. Form.:
C20H22N2
Mol. Mass.:
290.4021
SMILES:
Cc1ccc(CNC2CCc3c(C2)[nH]c2ccccc32)cc1
Structure:
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