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Target
Serine/threonine-protein kinase PAK 4
Ligand
BDBM50252772
Substrate
n/a
Meas. Tech.
ChEBML_1685098
IC50
1987±n/a nM
Citation
 Guo, J; Zhu, M; Wu, T; Hao, C; Wang, K; Yan, Z; Huang, W; Wang, J; Zhao, D; Cheng, M Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study. Bioorg Med Chem 25:3500-3511 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 4
Synonyms:
KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:
Protein
Mol. Mass.:
64098.01
Organism:
Homo sapiens (Human)
Description:
O96013
Residue:
591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
  
Inhibitor
Name:
BDBM50252772
Synonyms:
CHEMBL4061584
Type:
Small organic molecule
Emp. Form.:
C26H23N5O3
Mol. Mass.:
453.4925
SMILES:
Cn1cc(cn1)-c1cc2NC(=O)\C(=C/c3ccc[nH]3)c2cc1C(=O)N[C@H](CO)c1ccccc1 |r|
Structure:
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