Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM217044
Substrate
n/a
Meas. Tech.
ChEBML_1686176
Ki
19±n/a nM
Citation
 Curtin, ML; Heyman, HR; Clark, RF; Sorensen, BK; Doherty, GA; Hansen, TM; Frey, RR; Sarris, KA; Aguirre, AL; Shrestha, A; Tu, N; Woller, K; Pliushchev, MA; Sweis, RF; Cheng, M; Wilsbacher, JL; Kovar, PJ; Guo, J; Cheng, D; Longenecker, KL; Raich, D; Korepanova, AV; Soni, NB; Algire, MA; Richardson, PL; Marin, VL; Badagnani, I; Vasudevan, A; Buchanan, FG; Maag, D; Chiang, GG; Tse, C; Michaelides, MR SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 27:3317-3325 (2017) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM217044
Synonyms:
US9302989, 336
Type:
Small organic molecule
Emp. Form.:
C26H26N4O2
Mol. Mass.:
426.5102
SMILES:
O=C(Nc1ccc(cc1)N1CCN(CC1)C(=O)c1ccccc1)N1Cc2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: