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Target
S-adenosylmethionine decarboxylase proenzyme
Ligand
BDBM50254821
Substrate
n/a
Meas. Tech.
ChEBML_1686749
IC50
>180000±n/a nM
Citation
Volkov, OA; Brockway, AJ; Wring, SA; Peel, M; Chen, Z; Phillips, MA; De Brabander, JK Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. J Med Chem 61:1182-1203 (2018) [PubMed] Article
More Info.:
Target
Name:
S-adenosylmethionine decarboxylase proenzyme
Synonyms:
AMD | AMD1 | DCAM_HUMAN | S-Adenosylmethionine Decarboxylase (AdoMetDC) | S-adenosylmethionine decarboxylase 1 | SAMDC
Type:
Heterotetramer of two alpha and two beta chains
Mol. Mass.:
38337.21
Organism:
Homo sapiens (Human)
Description:
For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used.
Residue:
334
Sequence:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS