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Target
dCTP pyrophosphatase 1
Ligand
BDBM50260217
Substrate
n/a
Meas. Tech.
ChEBML_1693435
IC50
200±n/a nM
Citation
 Llona-Minguez, S; Häggblad, M; Martens, U; Johansson, L; Sigmundsson, K; Lundbäck, T; Loseva, O; Jemth, AS; Lundgren, B; Jensen, AJ; Scobie, M; Helleday, T Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems. Bioorg Med Chem Lett 27:3219-3225 (2017) [PubMed]  Article 
Target
Name:
dCTP pyrophosphatase 1
Synonyms:
DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:
Protein
Mol. Mass.:
18673.58
Organism:
Homo sapiens (Human)
Description:
Q9H773
Residue:
170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
  
Inhibitor
Name:
BDBM50260217
Synonyms:
CHEMBL4062129
Type:
Small organic molecule
Emp. Form.:
C18H19N5O2
Mol. Mass.:
337.3758
SMILES:
Cc1c(C)n2c(nc3n(C)c(=O)[nH]c(=O)c23)n1Cc1ccc(C)cc1
Structure:
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