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Target
ATP-dependent RNA helicase DDX39A
Ligand
BDBM50260459
Substrate
n/a
Meas. Tech.
ChEBML_1693898
IC50
>100000±n/a nM
Citation
 Tillotson, J; Kedzior, M; Guimarães, L; Ross, AB; Peters, TL; Ambrose, AJ; Schmidlin, CJ; Zhang, DD; Costa-Lotufo, LV; Rodríguez, AD; Schatz, JH; Chapman, E ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett 27:4082-4085 (2017) [PubMed]  Article 
Target
Name:
ATP-dependent RNA helicase DDX39A
Synonyms:
DDX39 | DDX39A | DEAD box protein 39 | DX39A_HUMAN | Nuclear RNA helicase URH49
Type:
PROTEIN
Mol. Mass.:
49121.92
Organism:
Homo sapiens
Description:
ChEMBL_117400
Residue:
427
Sequence:
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR
  
Inhibitor
Name:
BDBM50260459
Synonyms:
CHEMBL4099907
Type:
Small organic molecule
Emp. Form.:
C15H19BrO
Mol. Mass.:
295.215
SMILES:
C[C@H]1C(=C)CC[C@@]1(C)c1cc(Br)c(C)cc1O |r|
Structure:
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