Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 3
Ligand
BDBM50261065
Substrate
n/a
Meas. Tech.
ChEBML_1695439
IC50
27800±n/a nM
Citation
 Pan, X; Iyer, KA; Liu, H; Sweet, DH; Dukat, M A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3). Bioorg Med Chem Lett 27:4440-4445 (2017) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 3
Synonyms:
EMT | EMTH | Extraneuronal monoamine transporter | OCT3 | Organic cation transporter 3 | S22A3_HUMAN | SLC22A3
Type:
PROTEIN
Mol. Mass.:
61292.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_934315
Residue:
556
Sequence:
MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
  
Inhibitor
Name:
BDBM50261065
Synonyms:
CHEMBL1160766
Type:
Small organic molecule
Emp. Form.:
C7H8FN3
Mol. Mass.:
153.1569
SMILES:
NC(=N)Nc1ccc(F)cc1
Structure:
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