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Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50262427
Substrate
n/a
Meas. Tech.
ChEBML_1696823
EC50
1100±n/a nM
Citation
 Iwaki, T; Nakamura, Y; Tanaka, T; Ogawa, Y; Iwamoto, O; Okamura, Y; Kawase, Y; Furuya, M; Oyama, Y; Nagayama, T Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorg Med Chem Lett 27:4904-4907 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50262427
Synonyms:
CHEMBL4060401
Type:
Small organic molecule
Emp. Form.:
C31H42N6O2
Mol. Mass.:
530.7042
SMILES:
COc1cccc(c1)-c1ccc2nc(NC(C)C)nc(N[C@H]3CC[C@@H](CC3)NC(=O)C3CCCN(C)C3)c2c1 |r,wU:24.28,wD:21.21,(48.54,-18.83,;49.87,-18.06,;51.21,-18.82,;51.21,-20.36,;52.56,-21.13,;53.88,-20.36,;53.88,-18.82,;52.54,-18.05,;55.2,-18.05,;55.2,-16.5,;56.53,-15.74,;57.87,-16.51,;59.19,-15.73,;60.53,-16.5,;61.86,-15.72,;63.19,-16.49,;64.53,-15.71,;63.2,-18.03,;60.53,-18.05,;59.2,-18.82,;59.19,-20.36,;60.53,-21.13,;60.52,-22.67,;61.85,-23.44,;63.19,-22.67,;63.19,-21.13,;61.86,-20.35,;64.52,-23.45,;65.85,-22.68,;65.86,-21.14,;67.18,-23.46,;68.52,-22.69,;69.85,-23.47,;69.84,-25.02,;68.5,-25.77,;68.48,-27.31,;67.17,-25,;57.86,-18.05,;56.53,-18.82,)|
Structure:
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