Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50262458
Substrate
n/a
Meas. Tech.
ChEBML_1696823
EC50
170±n/a nM
Citation
 Iwaki, T; Nakamura, Y; Tanaka, T; Ogawa, Y; Iwamoto, O; Okamura, Y; Kawase, Y; Furuya, M; Oyama, Y; Nagayama, T Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorg Med Chem Lett 27:4904-4907 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50262458
Synonyms:
CHEMBL4073156
Type:
Small organic molecule
Emp. Form.:
C30H40N6O
Mol. Mass.:
500.6782
SMILES:
CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:11.14,wD:8.7,(18.04,-4.15,;16.71,-4.93,;16.71,-6.47,;15.37,-4.16,;14.04,-4.94,;14.05,-6.49,;12.71,-7.26,;12.71,-8.8,;14.04,-9.57,;14.03,-11.11,;15.36,-11.88,;16.7,-11.11,;16.7,-9.57,;15.37,-8.79,;18.03,-11.89,;19.37,-11.13,;19.37,-9.59,;20.7,-11.9,;22.03,-11.13,;23.36,-11.92,;23.35,-13.46,;22.01,-14.22,;22,-15.76,;20.69,-13.44,;11.37,-6.49,;10.05,-7.26,;8.72,-6.49,;8.71,-4.95,;10.05,-4.18,;11.38,-4.95,;12.7,-4.18,;7.39,-7.26,;6.05,-6.49,;4.72,-7.27,;4.72,-8.81,;6.07,-9.57,;7.4,-8.8,)|
Structure:
Search PDB for entries with ligand similarity: