Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50262474
Substrate
n/a
Meas. Tech.
ChEBML_1696823
EC50
260±n/a nM
Citation
 Iwaki, T; Nakamura, Y; Tanaka, T; Ogawa, Y; Iwamoto, O; Okamura, Y; Kawase, Y; Furuya, M; Oyama, Y; Nagayama, T Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorg Med Chem Lett 27:4904-4907 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50262474
Synonyms:
CHEMBL4082303
Type:
Small organic molecule
Emp. Form.:
C30H39ClN6O
Mol. Mass.:
535.123
SMILES:
CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(Cl)c1 |r,wU:11.14,wD:8.7,(63.87,-4.01,;62.54,-4.78,;62.55,-6.32,;61.2,-4.02,;59.87,-4.79,;59.88,-6.34,;58.54,-7.11,;58.54,-8.65,;59.87,-9.42,;59.87,-10.96,;61.19,-11.73,;62.53,-10.97,;62.54,-9.43,;61.2,-8.65,;63.86,-11.74,;65.2,-10.98,;65.21,-9.44,;66.53,-11.75,;67.86,-10.99,;69.19,-11.77,;69.18,-13.31,;67.84,-14.07,;67.83,-15.61,;66.52,-13.29,;57.21,-6.34,;55.88,-7.11,;54.55,-6.35,;54.55,-4.8,;55.88,-4.03,;57.21,-4.8,;58.54,-4.03,;53.22,-7.12,;53.23,-8.65,;51.9,-9.43,;50.56,-8.66,;50.56,-7.12,;49.22,-6.35,;51.89,-6.35,)|
Structure:
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