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Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50262485
Substrate
n/a
Meas. Tech.
ChEBML_1696823
EC50
310±n/a nM
Citation
 Iwaki, T; Nakamura, Y; Tanaka, T; Ogawa, Y; Iwamoto, O; Okamura, Y; Kawase, Y; Furuya, M; Oyama, Y; Nagayama, T Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorg Med Chem Lett 27:4904-4907 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50262485
Synonyms:
CHEMBL4098800
Type:
Small organic molecule
Emp. Form.:
C30H39FN6O
Mol. Mass.:
518.6687
SMILES:
CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2cc(ccc2n1)-c1ccc(F)cc1 |r,wU:11.14,wD:8.7,(41.96,-32.4,;40.63,-33.18,;40.64,-34.72,;39.29,-32.41,;37.96,-33.19,;37.97,-34.74,;36.63,-35.51,;36.63,-37.05,;37.97,-37.82,;37.96,-39.36,;39.28,-40.13,;40.62,-39.36,;40.63,-37.82,;39.29,-37.04,;41.95,-40.14,;43.29,-39.37,;43.3,-37.83,;44.62,-40.15,;45.95,-39.38,;47.28,-40.17,;47.27,-41.71,;45.93,-42.47,;45.92,-44,;44.61,-41.69,;35.3,-34.74,;33.97,-35.51,;32.64,-34.74,;32.64,-33.2,;33.97,-32.43,;35.3,-33.2,;36.63,-32.42,;31.31,-35.51,;29.98,-34.74,;28.65,-35.51,;28.65,-37.06,;27.32,-37.83,;29.99,-37.82,;31.32,-37.05,)|
Structure:
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