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Target
Similar to RIKEN cDNA 2010106G01 (Predicted)
Ligand
BDBM50263004
Substrate
n/a
Meas. Tech.
ChEBML_1697379
IC50
56±n/a nM
Citation
 Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem 61:865-880 (2018) [PubMed]  Article 
Target
Name:
Similar to RIKEN cDNA 2010106G01 (Predicted)
Synonyms:
Signal peptide peptidase-like 2A | Sppl2a
Type:
PROTEIN
Mol. Mass.:
59835.36
Organism:
Rattus norvegicus
Description:
ChEMBL_117518
Residue:
541
Sequence:
MGLLHSLHAPAAALLWSCLLGLSAAQEAILHASANGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTPLCHLSDIPPDGIKNKAVVVHWGPCHFLEKAKIAQEGGAAALLIANNSVLIPSSRNKSAFQNVTILIAVITQKDFNDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKEDYLTFSPLTVVLFVVICCVMIVLLYFFYKWLVYVMIAIFCIASATSLYNCLAALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKNDGNFVEATALHSAPHEKLPVVIRVPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDYSTNEENPAATDEQIVQQ
  
Inhibitor
Name:
BDBM50263004
Synonyms:
CHEMBL4069936
Type:
Small organic molecule
Emp. Form.:
C27H28FN5O4
Mol. Mass.:
505.5407
SMILES:
Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r|
Structure:
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